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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract:

Identification of the driver mutations in cancer has resulted in the development of a new categoryWhile most cancer therapies are given in combinations that are designed to avoid drug resistance, weThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell thatWe discuss the development of sequential drug therapies in which the first therapy is not given withcurative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively

Keywords： cancer drug resistance genetic screens senescence targeted therapy

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Translational research on novel drug-eluting stents in percutaneous coronary intervention

Yaling Han, Kai Xu, Chenghui Yan

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 395-400 doi: 10.1007/s11684-011-0167-1

Abstract: Although first-generation drug-eluting stents (DES) have markedly reduced restenosis, complications ofThe development of new DES is a key process to prevent these complications.Translational research plays a very important role in experiments which determine the safety and efficacyThe present review focuses on translational research of novel DES, including drug discovery, creationof preclinical research models, planning and conducting of first-in-man studies, and developing next-generation

Keywords： translational research drug-eluting stents percutaneous coronary intervention

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A Prospect on Research and Application of Natural Toxins

Chen Yisheng

Strategic Study of CAE 2003, Volume 5, Issue 2, Pages 16-19

Abstract: It is noteworthy that the toxin research gives impetus to drug discovery.information from toxin researches could provide valuable pharmacophoric pattern and structure motif for drugFurthermore, toxins are outstanding toos to explain and to search new target site of drugs.

Keywords： natural toxins control of biological toxicosis biogenic syntheses chemical biology chemical ecology newdrug research

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Prospect in Creating New Drugs from Chinese Herbal Medicine

Yu Dequan

Strategic Study of CAE 1999, Volume 1, Issue 2, Pages 87-90

Abstract: from Chinese herbal medicine has proved to be one of the most effective ways for the development of newThis paper describes the progress in creating new drugs based on researches on natural products chemistryfor many years and some interesting new trends emerging from recent literature.An intimate combination of basic study and drug development should be accomplished under a well-warranteeNatural product research should be featured by the application of modern spectroscopic techniques, such

Keywords： natural product research creating new drug chemical constituent of Chinese herbal medicine modem spectroscopic

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Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Strategic Study of CAE 2021, Volume 23, Issue 1, Pages 185-192 doi: 10.15302/J-SSCAE-2021.01.022

Abstract: ">drug research and development, innovation of traditional Chinese medicineThe research methods we used in this study includes literature research, academic exchange, and expertTo promote the new drug research and development based on integrative pharmacy, the design idea of integrative,and a new drug development system should be established for integrative drugs.It is a new pharmacy theory and practice system that can promote human health and improve the existing

Keywords： integrative pharmacy integrative drugs new drug development drug evaluation clinical medication guidance

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Wheat research and breeding in the new era of a high-quality reference genome

Rudi APPELS

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3, Pages 225-232 doi: 10.15302/J-FASE-2019265

Abstract:

The publications of the International Wheat Genome Sequencing Consortium (IWGSC) released in August 2018 are reviewed and placed into the context of developments arising from the availability of the high-quality wheat genome assembly.

Keywords： assembly technology molecular markers polyploidy transcript networks wheat genome

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1, Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drugIn addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation

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Strategy research on urban new space development and new deepwater port in Hengsha

Bao Qifan,Ren Guohua

Strategic Study of CAE 2013, Volume 15, Issue 6, Pages 14-19

Abstract: Construction of new deep-water terminal is the best usage of land resources and can strengthen the status

Keywords： urban development new space deepwater port strategy research

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 82-86 doi: 10.1007/s11705-009-0307-1

Abstract: A new supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonarydrug delivery (PDD).leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug

Keywords： advanced engineering improved pressure aqueous technique

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2, Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: These polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussedFinally, future prospects of developing new and better semi-solid excipients are discussed with the objective

Keywords： controlled release drug delivery semi-solids polymer excipient

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Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial

Feng Qi, Jie Wu, Hao Li, Guanghui Ma

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1, Pages 14-27 doi: 10.1007/s11705-018-1729-4

Abstract: L-lactic-co-glycolic acid) (PLGA)/poly(lactic acid) (PLA) microspheres/nanoparticles are one of the most successful drugsystem still has many problems during development and manufacturing, such as wide size distribution, drugRecently, many new and modified methods have been developed to overcome the above problems.Furthermore, the relevant FDA guidance on the DDS is still incomplete, especially for abbreviated newdrug application.

Keywords： PLGA microspheres drug delivery system stability manufacturing

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Research on New Mode and Business Model of Manufacturing Led by New-Generation Artificial Intelligence

Research Group for Research on New Mode and Business Model of Manufacturing Led by New-Generation Artificial

Strategic Study of CAE 2018, Volume 20, Issue 4, Pages 66-72 doi: 10.15302/J-SSCAE-2018.04.011

Abstract: manufacturing industry are facing major changes, which also provides opportunities for formation of newDriven by the new generation of artificial intelligence technology, new modes and business models generatedThe study has analyzed the development trends, typical types, and key platform technologies of the newbusiness models of manufacturing, and proposed the development guidelines, goals, and approaches for the new

Keywords： artificial intelligence manufacturing new mode new business model

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Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3, Pages 246-252 doi: 10.1007/s11705-012-1299-9

Abstract: The properties of the different kinds of spheres as drug delivery carriers were evaluated.Ibuprofen (IBU) was chosen as the model drug to load into the HA samples.The HA hollow spheres exhibited a higher drug loading capacity and more favorable release propertiesthan the HA solid spheres and thus are very promising for controlled drug release applications.

Keywords： hydroxyapatite hollow spheres synthesis drug release

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Concepts for the Construction of a New National Drug Service System

Wang Jian,Yuan Chunping,Wang Hao,Zhang Zhirong,Zhang Qiang,Chen Guiliang,Liu Changxiao,Hou Huimin and Yang Shengli

Strategic Study of CAE 2017, Volume 19, Issue 2, Pages 62-67 doi: 10.15302/J-SSCAE-2017.02.010

Abstract:

Although the current drug service system can meet the fundamental needsof healthcare in China, outstanding issues exist in all service sectors, including research and developmentspecialist consultation, and a panel discussion, this study investigated the current status of the drugWe propose an idea for constructing a new national drug service system to provide drugs to the Chinese

Keywords： drug service system pharmaceutical industry supervision development strategy

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drugvivax parasites were different across China and molecular markers could be used to rapidly monitor drugResults provided evidence for updating national drug policy and treatment guidelines.

Keywords： drug resistance antifolates molecular markers Plasmodium vivax China